The enzyme catalyzes the hydrolysis of fatty acids from the sn-2 position of glycerophospholipids to produce free fatty acids, such as arachidonic acid, and lyso PL. Many members of this family where reported to be Ca2+ dependent enzymes (PMID9020581).
CA 314 x IN THE RESTING STATE ENZYME
 |
Representative PDB structure for CA 314 x in the resting state enzyme | |
| PDB code | 1mkt | |
| Metal Type in the PDB | calcium | |
| Residue name of the metal in the PDB | CA | |
| Residue number of the metal in the PDB | 124 | |
| Chain of the metal in the PDB | _ | |
| Atom name of the metal in the PDB | CA | |
| Download the coordinates file of the metal site | ||
| First Coordination Sphere | ||||||
| Ligand Type | Ligand Identity | Residue In MACiE | Donors | Bind Mode | Catalytic? | Notes |
| residue | TYR 28 _ | TYR 28 B | O | monodentate | No | - |
| residue | GLY 30 _ | GLY 30 B | O | monodentate | Yes | Gly30 is an electrostatic stabilizer |
| residue | GLY 32 _ | GLY 32 B | O | monodentate | No | - |
| residue | ASP 49 _ | ASP 49 B | OD1,OD2 | bidentate | No | - |
| water | HOH 202 _ | - | O | monodentate | No | - |
| water | HOH 203 _ | - | O | monodentate | No | - |