The enzyme catalyzes the conversion of GTP to dihydroneopterin triphosphate. It is a homodecamer and each subunit binds an essential zinc ion (PMID11087827).
ZN 3316 A IN THE RESTING STATE ENZYME
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Representative PDB structure for ZN 3316 A in the resting state enzyme | |
| PDB code | 1fbx | |
| Metal Type in the PDB | zinc | |
| Residue name of the metal in the PDB | ZN | |
| Residue number of the metal in the PDB | 3316 | |
| Chain of the metal in the PDB | A | |
| Atom name of the metal in the PDB | ZN | |
| Download the coordinates file of the metal site | ||
| First Coordination Sphere | ||||||
| Ligand Type | Ligand Identity | Residue In MACiE | Donors | Bind Mode | Catalytic? | Notes |
| residue | CYS 110 A | CYS 141 A | SG | monodentate | No | - |
| residue | HIS 113 A | HIS 144 A | NE2 | monodentate | No | - |
| residue | CYS 181 A | CYS 212 A | SG | monodentate | No | - |
| water | HOH 3331 _ | - | O | monodentate | No | - |