The enzyme catalyzes the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in oligo-mannose oligosaccarides. It plays a critical role in the maturation of Asn-linked glycoproteins and triggers the signal for degradation of misfolded glycoproteins. It binds an essential calcium ion (PMID10995765).
CA 901 x IN THE RESTING STATE ENZYME
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Representative PDB structure for CA 901 x in the resting state enzyme | |
| PDB code | 1fmi | |
| Metal Type in the PDB | calcium | |
| Residue name of the metal in the PDB | CA | |
| Residue number of the metal in the PDB | 1 | |
| Chain of the metal in the PDB | A | |
| Atom name of the metal in the PDB | CA | |
| Download the coordinates file of the metal site | ||
| First Coordination Sphere | ||||||
| Ligand Type | Ligand Identity | Residue In MACiE | Donors | Bind Mode | Catalytic? | Notes |
| residue | THR 688 A | THR 525 A | O,OG1 | bidentate | No | - |
| water | HOH 1 _ | - | O | monodentate | No | - |
| water | HOH 2 _ | - | O | monodentate | No | - |
| water | HOH 3 _ | - | O | monodentate | No | - |
| water | HOH 4 _ | - | O | monodentate | No | - |
| water | HOH 5 _ | - | O | monodentate | No | - |
| water | HOH 6 _ | - | O | monodentate | No | - |