The enzyme catalyzes the oxidation of halides in the presence of hydrogen peroxide to the corresponding hypohalous acids (PMID8552646). It uses a vanadium ion to perform the catalysis (PMID9165086).
VO4 579 x IN THE RESTING STATE ENZYME
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Representative PDB structure for VO4 579 x in the resting state enzyme | |
| PDB code | 1idu | |
| Metal Type in the PDB | vanadium | |
| Residue name of the metal in the PDB | VO4 | |
| Residue number of the metal in the PDB | 1579 | |
| Chain of the metal in the PDB | A | |
| Atom name of the metal in the PDB | V | |
| Download the coordinates file of the metal site | NOTES ON PDB: | |
| First Coordination Sphere | ||||||
| Ligand Type | Ligand Identity | Residue In MACiE | Donors | Bind Mode | Catalytic? | Notes |
| residue | HIS 496 A | HIS 496 _ | NE2 | monodentate | Yes | His496 is covalently bound to vanadate (PMID10446144). |
| cofactor | VO4 1579 A | - | O1,O2,O3,O4 | tetradentate | No | These four oxygen atoms are covalently bound to vanadium to form vanadate. |