The CoFactor database
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CoFactor - The organic enzyme cofactor database

v2.1.1 29 September 2011.

About CoFactor

Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database. It provides a web interface to access hand-curated data extracted from the literature on the 27 organic enzyme cofactors, as well as automatically collected information. CoFactor includes information on the conformational and solvent accessibility variation of the enzyme-bound cofactors, including mechanistic and structural information about the hosting enzymes. The project is closely related to the MACiE database.


This service is provided by the Thornton research group at EBI. For questions, suggestions or bug reports, please contact us using the contact form.

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  1. Julia D. Fischer, Gemma L. Holliday, and Janet M. Thornton: The CoFactor database: Organic cofactors in enzyme catalysis. (2010) Bioinformatics. 26 (19): 2496-2497.
  2. Julia D. Fischer, Gemma L. Holliday, Syed A. Rahman and Janet M. Thornton: The structures and physicochemical properties of organic cofactors in biocatalysis. (2010) JMB. 403 (5): 803-824.
  3. Gemma L. Holliday, Julia D. Fischer, John B. O. Mitchell and Janet M. Thornton: Characterizing the complexity of enzymes on the basis of their mechanisms and structures with a bio-computational analysis. (2011) FEBS J.