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Sequence Similarity Search (SSS) is a method of searching sequence databases by using alignment to a query sequence. By statistically assessing how well database and query sequences match one can infer homology and transfer information to the query sequence.

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 REST ServiceDescription
FASTA Fast protein or nucleotide comparison using the FASTA suite. Includes Smith and Waterman local-local (SSEARCH), global-local (GLSEARCH) and global-global (GGSEARCH) alignment searches.
FASTM Peptide fragment searches using the FASTF, FASTM or FASTS programs from the FASTA suite.
NCBI BLAST+Compare a sequence with those contained in nucleotide and protein databases using NCBI BLAST.
PSI-BLAST Position Specific Iterative BLAST (PSI-BLAST), guided mode
PSI-SearchIterative Smith and Waterman using a PSI-BLAST strategy
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