Project PXD004465

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Summary

Title

Glycoproteomics reveals the presence of decorin peptides with anti-myostatin activity in human atrial fibrillation

Description

We analysed by proteomics the cardiac extraceelular matrix in human atrial fibrillation and disvovered the presence of extracellular matrix protein fragments that can regulate cardiac cell physiology

Sample Processing Protocol

Samples were extracted using a 3-step protocol for extracellular matrix protein enrichment. Proteins were deglycosylated and run in Bis-tris gels. After trypsin digestion, proteins were identified using LC-MS/MS in an Orbitrap XL instrument.

Data Processing Protocol

MS data were searched using Mascot agains a human database 12013_08

Contact

Javier Barallobre-Barreiro, King's college London
Manuel Mayr, King's College London ( lab head )

Submission Date

09/08/2016

Publication Date

29/09/2016

Publication

    Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016 Sep 13;134(11):817-32 PubMed: 27559042

Assay

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Showing 1 - 10 of 167 results
# Accession Title Proteins Peptides Unique Peptides Spectra Identified Spectra View in Reactome
1 67025 POAF-01 band 6 164 2026 737 2980 1329
2 67146 POAF-01 band 7 226 2330 1060 2846 1427
3 67026 POAF-01 band 8 225 2627 1111 2821 1480
4 67147 POAF-01 band 9 208 2167 987 2791 1327
5 67023 POAF-01 band 10 240 2305 1198 2797 1509
6 67144 POAF-01 band 1 188 1935 818 2724 1088
7 67024 POAF-01 band 11 206 2191 1124 2736 1506
8 67145 POAF-01 band 12 221 2389 1037 2800 1475
9 67029 POAF-01 band 2 232 1923 858 2769 1296
10 67027 POAF-01 band 3 224 2096 935 2786 1314