Project PXD000050

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The human islet of Langerhans proteome database


Type 2 diabetes is a worldwide disease reaching epidemic dimensions. The rapid progression of the disease urgently calls for both a broader and deeper understanding of its pathophysiology. In line with this statement, the Human Diabetes Proteome Project (HDPP) was officially launched at the 11th HUPO meeting in Boston, 2012. A special session was dedicated to this new initiative, gathering experts in the main topics related to diabetes and its associated complications. Key issues were debated with a focus on how deranged circulating glucose and free fatty acids induce dysfunction. It has been decided that HDPP will therefore focus on studying the early stages of diabetes that lead to abnormal glucose and lipid levels. The initiative will initially focused on islets of Langerhans, insulin-producing cell lines, and blood human samples from diabetes-related cohorts. In subsequent stages HDPP will investigate target tissues in which glucose and lipids could promote protein dysfunctions. Omics-rooted systems approaches enhanced by bioinformatics will be deployed to unravel effects of lipids and glucose triggering diabetes initiation and progression. A first milestone has been defined for the 12th HUPO meeting in Yokohama, 2013: the 1000 diabetes-associated protein (the 1000-HDPP) database, i.e. a freely available internet resource ( of more than 1000 proteins with links to their corresponding proteotypic peptides, affinity reagents and protein-specific biological/biomedical information. Human islets digested and seperated by off-gel electrophoresis. Analysis by LTQ-Orbitrap velos mass spectrometer (fragmentation by CID,gaz phase fractionnation with four m/z windows: 400-520, 515-690, 685-979, 974-2000)

Sample Processing Protocol

Not available

Data Processing Protocol

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Domitille Schvartz, structural biology and bioinformatics

Submission Date


Publication Date



Not available


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Experiment Type

Bottom-up proteomics

Assay count



Publication pending


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Showing 1 - 10 of 12 results
# Accession Title Proteins Peptides Unique Peptides Spectra Identified Spectra View in Reactome
1 27518 Betajudo N1727_GPF4_merge_fraction1_exp1.3 2223 8804 4492 135156 8246
2 27519 Betajudo N1727_GPF4_merge_fraction2_exp1.3 1405 4129 2008 122937 4030
3 27520 Betajudo N1727_GPF4_merge_fraction3_exp1.3 648 1475 778 128694 1358
4 27521 Betajudo N1727_GPF4_merge_fraction4_exp1.3 1917 5400 3083 134948 5100
5 27522 Betajudo N1727_GPF4_merge_fraction5_exp1.3 2253 6254 3561 135380 5883
6 27523 Betajudo N1727_GPF4_merge_fraction6_exp1.3 1095 2662 1396 127810 2634
7 27524 Betajudo N1727_GPF4_merge_fraction8_exp1.3 1089 2327 1353 127992 2277
8 27525 Betajudo N1727_GPF4_merge_fraction8_exp1.3 1089 2327 1353 127992 2277
9 27526 Betajudo N1727_GPF4_merge_fraction9_exp1.3 158 223 165 123320 221
10 27527 Betajudo N1727_GPF4_merge_fraction10_exp1.3 418 632 450 122535 632