PDBsum entry 9rf5

Hydrolase

PDB id: 9rf5

Contents

Protein chain

278 a.a.

Ligands

8D5

MPD

EDO

PGE

PEG

Waters ×81

PDB id:

9rf5

Name:

Hydrolase

Title:

M. Tuberculosis meets european lead factory: identification and structural characterization of novel rv0183 inhibitors using x-ray crystallography: elf8

Structure:

Monoacylglycerol lipase. Chain: a. Synonym: mgl. Engineered: yes. Mutation: yes

Source:

Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Gene: rv0183. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.80Å R-factor: 0.168 R-free: 0.202

Authors:

L.Riegler-Berket,L.Goedl,M.Oberer,N.Polidori

Key ref:

L.Riegler-Berket et al. M. Tuberculosis meets european lead factory: identifi and structural characterization of novel rv0183 inhib using X-Ray crystallography. To be published, .

Date:

04-Jun-25 Release date: 13-Aug-25

Protein chain

O07427  (MGLL_MYCTU) -  Monoacylglycerol lipase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 279 a.a.

Struc: 278 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.1.23 - acylglycerol lipase.
• Reaction: Hydrolyzes glycerol monoesters of long-chain fatty acids.