PDBsum entry 9qb5

Transferase

PDB id: 9qb5

Contents

Protein chains

314 a.a.

Ligands

F7I ×2

SO4 ×5

Waters ×149

PDB id:

9qb5

Name:

Transferase

Title:

Ap2-associated protein kinase 1 (aak1) bound to ckjb68

Structure:

Ap2-associated protein kinase 1. Chain: a, b. Synonym: adaptor-associated kinase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: aak1, kiaa1048. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å R-factor: 0.199 R-free: 0.227

Authors:

F.Preuss,T.E.Mensing,T.Hanke,S.Knapp,S.Mathea

Key ref:

F.Preuss et al. Ap2-Associated protein kinase 1 (aak1) bound to ckjb6. To be published, . PubMed id: 40882436

Date:

28-Feb-25 Release date: 09-Apr-25

Protein chains

Q2M2I8  (AAK1_HUMAN) -  AP2-associated protein kinase 1 from Homo sapiens

Seq: 961 a.a.

Struc: 314 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site