PDBsum entry 9n4t

Membrane protein

PDB id: 9n4t

Contents

Protein chains

842 a.a.

329 a.a.

Ligands

NAG-NAG-BMA-MAN-MAN ×4

NAG-NAG ×4

NAG-NAG-BMA-BMA ×2

2J9 ×4

KAI ×4

POV ×18

NAG ×20

PDB id:

9n4t

Name:

Membrane protein

Title:

Composite map for gluk2-2xneto2 in the open state, in complex with the positive allosteric modulator bpam344 and agonist kainate

Structure:

Glutamate receptor ionotropic, kainate 2. Chain: a, b, c, d. Synonym: gluk2,glutamate receptor 6,glur-6,glur6. Engineered: yes. Neuropilin and tolloid-like protein 2. Chain: e, f. Synonym: brain-specific transmembrane protein containing 2 cub and 1 ldl-receptor class a domains protein 2. Engineered: yes

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: grik2, glur6. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: neto2, btcl2. Expression_system_taxid: 9606

Authors:

S.P.Gangwar,M.V.Yelshanskaya,L.Y.Yen,T.P.Newton,A.I.Sobolevsky

Key ref:

S.P.Gangwar et al. Activation of kainate receptor gluk2-Neto2 complex.. Nat.Struct.Mol.Biol., . PubMed id: 40846810 DOI: 10.1038/S41594-025-01656-9

Date:

03-Feb-25 Release date: 17-Sep-25

Protein chains

P42260  (GRIK2_RAT) -  Glutamate receptor ionotropic, kainate 2 from Rattus norvegicus

Seq: 908 a.a.

Struc: 842 a.a.*

Protein chains

C6K2K4  (NETO2_RAT) -  Neuropilin and tolloid-like protein 2 from Rattus norvegicus

Seq: 525 a.a.

Struc: 329 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)