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PDBsum entry 9n0s
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Transferase, viral protein
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PDB id
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9n0s
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Contents |
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1607 a.a.
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56 a.a.
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41 a.a.
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PDB id:
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| Name: |
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Transferase, viral protein
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Title:
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3.47a bornavirus l-p complex (after incubation with RNA/ntp) (state 2)
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Structure:
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RNA-directed RNA polymerase. Chain: a. Synonym: replicase,transcriptase. Engineered: yes. P protein. Chain: b, c, d, e. Engineered: yes
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Source:
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Orthobornavirus. Organism_taxid: 186458. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Authors:
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B.Liu,G.Yang,D.Wang
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Key ref:
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B.Liu
et al.
Cryo-Em structure of the bornavirus polymerase (l) pr in complex with the tetrameric phosphoprotein (p) - ( Incubation with rna/ntp) (state 2).
To be published,
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PubMed id:
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Date:
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24-Jan-25
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Release date:
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10-Sep-25
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PROCHECK
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Headers
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References
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A0A6C6W7Z6
(A0A6C6W7Z6_BDV1) -
RNA-directed RNA polymerase from Borna disease virus 1
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Seq:
Struc:
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1711 a.a.
1607 a.a.*
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Enzyme class 2:
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Chain A:
E.C.2.1.1.375
- Nns virus cap methyltransferase.
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Reaction:
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a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl- adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H+
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5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA
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+
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2
×
S-adenosyl-L-methionine
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=
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5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl- adenosine in mRNA
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+
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2
×
S-adenosyl-L-homocysteine
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+
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H(+)
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Enzyme class 3:
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Chain A:
E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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2
×
ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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2
×
diphosphate
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Enzyme class 4:
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Chain A:
E.C.2.7.7.88
- Gdp polyribonucleotidyltransferase.
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Reaction:
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a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl- adenosine in mRNA + diphosphate
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5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA
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+
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2
×
GDP
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+
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H(+)
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=
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2
×
5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl- adenosine in mRNA
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+
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diphosphate
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
