PDBsum entry 9ipc

Antitumor protein/immune system

PDB id: 9ipc

Contents

Protein chains

539 a.a.

465 a.a.

168 a.a.

PDB id:

9ipc

Name:

Antitumor protein/immune system

Title:

Poly-alanine model for lh-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (closed conformation)

Structure:

Epidermal growth factor receptor. Chain: a. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes. Lh-type bispecific diabody ex3. Chain: b. Engineered: yes. Mutation: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.

Authors:

K.Sato,S.Uehara,A.Tsugita,T.Matsui,R.Asano,K.Makabe,T.Yokoyama, Y.Tanaka

Key ref:

K.Sato et al. Bispecific antibody-Antigen complex structures reveal activity enhancement by domain rearrangement. Cell rep, . PubMed id: 40664209

Date:

10-Jul-24 Release date: 28-May-25

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 539 a.a.

Protein chain

No UniProt id for this chain

Struc: 465 a.a.

Protein chain

P07766  (CD3E_HUMAN) -  T-cell surface glycoprotein CD3 epsilon chain from Homo sapiens

Seq: 207 a.a.

Struc: 168 a.a.*

Protein chain

P09693  (CD3G_HUMAN) -  T-cell surface glycoprotein CD3 gamma chain from Homo sapiens

Seq: 182 a.a.

Struc: 168 a.a.*

* PDB and UniProt seqs differ at 103 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site