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PDBsum entry 9i6f
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protein ligands metals Protein-protein interface(s) links
Membrane protein PDB id
9i6f

 

 

 

 

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Contents
Protein chains
76 a.a.
513 a.a.
222 a.a.
261 a.a.
139 a.a.
105 a.a.
92 a.a.
75 a.a.
83 a.a.
71 a.a.
58 a.a.
51 a.a.
47 a.a.
43 a.a.
Ligands
PEE ×4
HEA ×2
PGV
CDL
Metals
_CU ×3
_ZN
_MG
PDB id:
9i6f
Name: Membrane protein
Title: Cryo-em structure of higd2a bound complex iv
Structure: Hig1 domain family member 2a, mitochondrial. Chain: n. Synonym: rcf1 homolog b,rcf1b. CytochromE C oxidase subunit 1. Chain: a. Synonym: cytochromE C oxidase polypeptide i. CytochromE C oxidase subunit 2. Chain: b. Synonym: cytochromE C oxidase polypeptide ii.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Authors: M.D.Nguyen,J.Rorbach,V.Singh
Key ref: M.D.Nguyen et al. Structural basis for late maturation steps of mitocho respiratory chain complex IV within the human respira. To be published, .
Date:
30-Jan-25     Release date:   03-Dec-25    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9BW72  (HIG2A_HUMAN) -  HIG1 domain family member 2A, mitochondrial from Homo sapiens
Seq:
Struc: 		106 a.a.
76 a.a.
Protein chain
Pfam   ArchSchema ?
P00395  (COX1_HUMAN) -  Cytochrome c oxidase subunit 1 from Homo sapiens
Seq:
Struc: 		513 a.a.
513 a.a.*
Protein chain
Pfam   ArchSchema ?
P00403  (COX2_HUMAN) -  Cytochrome c oxidase subunit 2 from Homo sapiens
Seq:
Struc: 		227 a.a.
222 a.a.
Protein chain
Pfam   ArchSchema ?
P00414  (COX3_HUMAN) -  Cytochrome c oxidase subunit 3 from Homo sapiens
Seq:
Struc: 		261 a.a.
261 a.a.*
Protein chain
Pfam   ArchSchema ?
P13073  (COX41_HUMAN) -  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial from Homo sapiens
Seq:
Struc: 		169 a.a.
139 a.a.
Protein chain
Pfam   ArchSchema ?
P20674  (COX5A_HUMAN) -  Cytochrome c oxidase subunit 5A, mitochondrial from Homo sapiens
Seq:
Struc: 		150 a.a.
105 a.a.
Protein chain
Pfam   ArchSchema ?
P10606  (COX5B_HUMAN) -  Cytochrome c oxidase subunit 5B, mitochondrial from Homo sapiens
Seq:
Struc: 		129 a.a.
92 a.a.
Protein chain
Pfam   ArchSchema ?
P12074  (CX6A1_HUMAN) -  Cytochrome c oxidase subunit 6A1, mitochondrial from Homo sapiens
Seq:
Struc: 		109 a.a.
75 a.a.
Protein chain
Pfam   ArchSchema ?
P14854  (CX6B1_HUMAN) -  Cytochrome c oxidase subunit 6B1 from Homo sapiens
Seq:
Struc: 		86 a.a.
83 a.a.
Protein chain
Pfam   ArchSchema ?
P09669  (COX6C_HUMAN) -  Cytochrome c oxidase subunit 6C from Homo sapiens
Seq:
Struc: 		75 a.a.
71 a.a.
Protein chain
Pfam   ArchSchema ?
P14406  (CX7A2_HUMAN) -  Cytochrome c oxidase subunit 7A2, mitochondrial from Homo sapiens
Seq:
Struc: 		83 a.a.
58 a.a.
Protein chain
Pfam   ArchSchema ?
P24311  (COX7B_HUMAN) -  Cytochrome c oxidase subunit 7B, mitochondrial from Homo sapiens
Seq:
Struc: 		80 a.a.
51 a.a.
Protein chain
Pfam   ArchSchema ?
P15954  (COX7C_HUMAN) -  Cytochrome c oxidase subunit 7C, mitochondrial from Homo sapiens
Seq:
Struc: 		63 a.a.
47 a.a.
Protein chain
Pfam   ArchSchema ?
P10176  (COX8A_HUMAN) -  Cytochrome c oxidase subunit 8A, mitochondrial from Homo sapiens
Seq:
Struc: 		69 a.a.
43 a.a.
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B, C: E.C.7.1.1.9  - cytochrome-c oxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 × Fe(II)-[cytochrome c]
 + O2
 + 8 × H(+)(in)
 = 4 × Fe(III)-[cytochrome c]
 + 2 × H2O
 + 4 × H(+)(out)
      Cofactor: Cu cation
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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