PDBsum entry 9grh

Biosynthetic protein

PDB id: 9grh

Contents

Protein chains

481 a.a.

Metals

_ZN ×4

PDB id:

9grh

Name:

Biosynthetic protein

Title:

Crystal structure of thE C-terminal phosphatase domain from saccharomyces cerevisiae vip1 (apo)

Structure:

Inositol hexakisphosphate and diphosphoinositol- pentakisphosphate kinase. Chain: a, b, c, d. Synonym: insp6 and pp-ip5 kinase. Engineered: yes

Source:

Saccharomyces cerevisiae. Brewer's yeast. Organism_taxid: 4932. Gene: vip1, ylr410w. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tnao

Resolution:

3.20Å R-factor: 0.225 R-free: 0.276

Authors:

P.Raia,K.Lee,M.Hothorn

Key ref:

P.Raia et al. (2025). A small signaling domain controls ppip5k phosphatase activity in phosphate homeostasis.. Nat commun, 16, 1753. PubMed id: 39966396 DOI: 10.1038/S41467-025-56937-0

Date:

11-Sep-24 Release date: 26-Feb-25

Protein chains

Q06685  (VIP1_YEAST) -  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 1146 a.a.

Struc: 481 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.4.24 - diphosphoinositol-pentakisphosphate 1-kinase.
• Reaction:
  1. 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
  2. 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H⁺ = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP

Molecule diagrams generated from .mol files obtained from the KEGG ftp site