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PDBsum entry 9fk5
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protein Protein-protein interface(s) links
Membrane protein PDB id
9fk5

 

 

 

 

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Contents
Protein chains
112 a.a.
112 a.a.
77 a.a.
105 a.a.
329 a.a.
PDB id:
9fk5
Name: Membrane protein
Title: Zebrafish betaglycan orphan domain (zfbgo) in complex with tgf-b3 and extracellular domains of tgfbri and tgfbrii
Structure: Transforming growth factor beta-3. Chain: a. Synonym: tgf-beta-3. Engineered: yes. Transforming growth factor beta-3. Chain: b. Synonym: tgf-beta-3. Engineered: yes. Mutation: yes.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tgfbr1, alk5, skr4. Gene: tgfbr2. Danio rerio.
Authors: L.Wieteska,J.A.Coleman,A.P.Hinck
Key ref: L.Wieteska et al. (2025). Structures of tgf-Beta with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling.. Nat commun, 16, 1778. PubMed id: 40011426 DOI: 10.1038/S41467-025-56796-9
Date:
02-Jun-24     Release date:   12-Mar-25    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P10600  (TGFB3_HUMAN) -  Transforming growth factor beta-3 proprotein from Homo sapiens
Seq:
Struc: 		412 a.a.
112 a.a.
Protein chain
Pfam   ArchSchema ?
P10600  (TGFB3_HUMAN) -  Transforming growth factor beta-3 proprotein from Homo sapiens
Seq:
Struc: 		412 a.a.
112 a.a.*
Protein chain
Pfam   ArchSchema ?
P36897  (TGFR1_HUMAN) -  TGF-beta receptor type-1 from Homo sapiens
Seq:
Struc: 		503 a.a.
77 a.a.
Protein chain
Pfam   ArchSchema ?
P37173  (TGFR2_HUMAN) -  TGF-beta receptor type-2 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		567 a.a.
105 a.a.
Protein chain
Pfam   ArchSchema ?
A0A0H3UK16  () -  Transforming growth factor beta receptor III from Danio rerio
Seq:
Struc: 		 
Seq:
Struc: 		848 a.a.
329 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains C, D: E.C.2.7.11.30  - receptor protein serine/threonine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor- protein] + ADP + H+
2. L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor- protein] + ADP + H+
L-seryl-[receptor-protein]
 + ATP
 = O-phospho-L-seryl-[receptor- protein]
 + ADP
 + H(+)
L-threonyl-[receptor-protein]
 + ATP
 = O-phospho-L-threonyl-[receptor- protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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