PDBsum entry 9f8h

Biosynthetic protein

PDB id: 9f8h

Contents

Protein chains

154 a.a.

Ligands

RAL ×2

GOL ×2

EDO

Waters ×264

PDB id:

9f8h

Name:

Biosynthetic protein

Title:

Crystal structure of phza/b from burkholderia cepacia r18194 in complex with raloxifene

Structure:

Phenazine biosynthesis protein a/b. Chain: a, b. Engineered: yes

Source:

Burkholderia lata. Organism_taxid: 482957. Gene: bcep18194_b1568. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.47Å R-factor: 0.135 R-free: 0.164

Authors:

C.Diederich,M.Zimmermann,M.Thiemann,C.Kunick,W.Blankenfeldt

Key ref:

M.Thiemann et al. (2025). From bones to bugs: structure-Based development of raloxifene-Derived pathoblockers that inhibit pyocyan production in pseudomonas aeruginosa.. J med chem, 68, 7390. PubMed id: 40156840

Date:

06-May-24 Release date: 16-Apr-25

Protein chains

Q396C9  (Q396C9_BURL3) -  Phenazine biosynthesis protein A/B from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)

Seq: 165 a.a.

Struc: 154 a.a.