PDBsum entry 9emc

Chaperone

PDB id: 9emc

Contents

Protein chains

322 a.a.

337 a.a.

Ligands

ATP ×6

Metals

_MG ×6

PDB id:

9emc

Name:

Chaperone

Title:

Ruvbl1/2 in complex with atp

Structure:

Ruvb-like 1. Chain: a, b, c. Synonym: 49 kda tata box-binding protein-interacting protein,49 kda tbp-interacting protein,54 kda erythrocyte cytosolic protein,ecp-54, ino80 complex subunit h,nuclear matrix protein 238,nmp 238,pontin 52, tip49a,tip60-associated protein 54-alpha,tap54-alpha. Engineered: yes. Other_details: sequence contains three extra aminoacids (gsh) at the n-terminus due to protease cleavage that do not affect the structure

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ruvbl1, ino80h, nmp238, tip49, tip49a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ruvbl2, ino80j, tip48, tip49b, cgi-46. Expression_system_taxid: 562

Authors:

A.Lopez-Perrote,O.Llorca,C.Garcia-Martin

Key ref:

C.Garcia-Martin et al. Mechanism of allosteric inhibition of ruvbl1-Ruvbl2 b small-Molecule cb-6644. Cell rep phys sci, . DOI: 10.1016/J.XCRP.2024.101982

Date:

08-Mar-24 Release date: 15-May-24

Protein chains

Q9Y265  (RUVB1_HUMAN) -  RuvB-like 1 from Homo sapiens

Seq: 456 a.a.

Struc: 322 a.a.

Protein chains

Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens

Seq: 463 a.a.

Struc: 337 a.a.

Enzyme reactions

• Enzyme class: Chains A, D, B, C, F, E: E.C.3.6.4.12 - Dna helicase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

ATP (Bound ligand (Het Group name = ATP) corresponds exactly) + H2O = ADP + phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site