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PDBsum entry 9eet
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Hydrolase/inhibitor
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PDB id
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9eet
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PDB id:
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| Name: |
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Hydrolase/inhibitor
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Title:
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Crystal structure of the sars-cov-2 nsp5 main protease (mpro) e166v mutant in complex with inhibitor gc376
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Structure:
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3c-like proteinase nsp5. Chain: a. Fragment: unp residues 3264-3569. Synonym: 3cl-pro,3clp,main protease,mpro,non-structural protein 5, nsp5,sars coronavirus main proteinase. Engineered: yes. Mutation: yes
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Source:
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Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049. Variant: wa1. Gene: rep, 1a-1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: ril
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Resolution:
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2.39Å
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R-factor:
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0.195
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R-free:
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0.229
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Authors:
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G.Neilsen,K.A.Kirby,S.G.Sarafianos
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Key ref:
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G.Neilsen
et al.
(2025).
Strategy to overcome a nirmatrelvir resistance mechan the sars-Cov-2 nsp5 protease..
Sci adv,
11,
v8875.
PubMed id:
DOI:
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Date:
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19-Nov-24
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Release date:
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18-Jun-25
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PROCHECK
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Headers
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References
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P0DTD1
(R1AB_SARS2) -
NSP5 - main protease (306 aa)
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Seq:
Struc:
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306 a.a.
306 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Links
