 |
PDBsum entry 9dw3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Structural protein
|
PDB id
|
|
|
|
9dw3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Structural protein
|
|
|
Title:
|
|
Human mitochondrial clpp in complex with bortezomib
|
|
Structure:
|
|
Atp-dependent clp protease proteolytic subunit, mitochondrial. Chain: a, b, c, d, e, f, g, h, i, j, k, l, m, n. Synonym: endopeptidase clp. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: clpp. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Authors:
|
|
W.Chen
|
|
Key ref:
|
|
W.C.Chen
Assembly and proteolytic activation human clpxp defin cryo-Em.
To be published,
.
|
|
|
Date:
|
|
|
08-Oct-24
|
Release date:
|
15-Oct-25
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q16740
(CLPP_HUMAN) -
ATP-dependent Clp protease proteolytic subunit, mitochondrial from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
277 a.a.
181 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
|
*
PDB and UniProt seqs differ
at 4 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.3.4.21.92
- endopeptidase Clp.
|
|
|
|
|
|
|
Reaction:
|
|
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved (such as succinyl-Leu-Tyr-|-NHMEC; and Leu-Tyr-Leu-|-Tyr-Trp, in which the cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp- bond also occurs).
|
|
|
|
|
|
|
|
Links
