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PDBsum entry 9dnn
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protein Protein-protein interface(s) links
Signaling protein PDB id
9dnn

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
820 a.a.
48 a.a.
65 a.a.
PDB id:
9dnn
Name: Signaling protein
Title: Insulin receptor in complex with both insulin and de novo designed site-2 binder "s2b".
Structure: Insulin receptor. Chain: a, b. Synonym: ir. Engineered: yes. Insulin. Chain: c, d. Engineered: yes. Designed site-2 binder s2b. Chain: e, f.
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
Authors: X.C.Bai
Key ref: X.C.Bai Tuning insulin receptor signaling using de novo desig agonists. To be published, . PubMed id: 41086805
Date:
17-Sep-24     Release date:   01-Oct-25    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P15208  (INSR_MOUSE) -  Insulin receptor from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1372 a.a.
820 a.a.
Protein chains
Pfam   ArchSchema ?
P01308  (INS_HUMAN) -  Insulin from Homo sapiens
Seq:
Struc: 		110 a.a.
48 a.a.
Protein chains
No UniProt id for this chain
Struc: 65 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.2.7.10.1  - receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
 + ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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