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PDBsum entry 9d7c

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protein ligands Protein-protein interface(s) links
Hydrolase/inhibitor PDB id
9d7c

 

 

 

 

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Contents
Protein chains
236 a.a.
Ligands
Y33 ×4
CO2 ×2
Waters ×208
PDB id:
9d7c
Name: Hydrolase/inhibitor
Title: Oxa-58-na-1-157 10 min complex
Structure: Beta-lactamase. Chain: a, b, c, d. Engineered: yes
Source: Acinetobacter baumannii. Organism_taxid: 470. Gene: blaoxa-58, bla-oxa-58, bla-oxa58, gse42_20550, p9867_20895. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.94Å     R-factor:   0.220     R-free:   0.249
Authors: C.A.Smith,A.O.Maggiolo,M.Toth,S.B.Vakulenko
Key ref: M.Toth et al. Decarboxylation of the catalytic lysine residue by th alpha-Methyl-Substituted carbapenem na-1-157 leads to inhibition of the oxa-58 carbapenemase.. Acs infect dis, . PubMed id: 39601221
Date:
16-Aug-24     Release date:   11-Dec-24    
PROCHECK
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 Headers
 References

Protein chains
Q2TR58  (OXA58_ACIBA) -  Beta-lactamase OXA-58 from Acinetobacter baumannii
Seq:
Struc:
280 a.a.
236 a.a.
Key:    Secondary structure

 Enzyme reactions 
   Enzyme class: E.C.3.5.2.6  - beta-lactamase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Penicillin Biosynthesis and Metabolism
      Reaction: a beta-lactam + H2O = a substituted beta-amino acid
      Cofactor: Zn(2+)

 

 

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