PDBsum entry 9d6c

Virus like particle

PDB id: 9d6c

Contents

Protein chains

(+ 12 more) 232 a.a.

Ligands

QNG ×18

2I4 ×7

IHP ×7

Waters ×378

PDB id:

9d6c

Name:

Virus like particle

Title:

Gag ca-sp1 immature lattice bound with lenacapavir and bevirimat from enveloped virus like particles

Structure:

Gag. Chain: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r. Fragment: ca-sp1 domains (unp residues 141-372). Engineered: yes. Mutation: yes

Source:

Human immunodeficiency virus type 1 group m subtype b (isolate hxb2). Organism_taxid: 11706. Strain: isolate hxb2. Gene: gag. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t. Expression_system_atcc_number: crl-3216.

Authors:

C.Wu,M.E.Meuser,Y.Xiong

Key ref:

C.Wu et al. Structural insights into inhibitor mechanisms on imma HIV-1 gag lattice revealed by high-Resolution in situ single-Particle cryo-Em.. Biorxiv, . PubMed id: 39416065

Date:

14-Aug-24 Release date: 30-Oct-24

Protein chains

P04591  (GAG_HV1H2) -  Gag polyprotein from Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)

Seq: 500 a.a.

Struc: 232 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)