PDBsum entry 9ctf

Membrane protein,translocase

PDB id: 9ctf

Contents

Protein chain

1158 a.a.

Ligands

UPL ×22

ATP

TA1

PDB id:

9ctf

Name:

Membrane protein,translocase

Title:

Sapnp reconstituted human abcb1 bound to taxol in presence of atp

Structure:

Atp-dependent translocase abcb1. Chain: a. Synonym: atp-binding cassette sub-family b member 1,multidrug resistance protein 1,p-glycoprotein 1,phospholipid transporter abcb1. Engineered: yes. Other_details: sapnp reconstituted human abcb1 bound to taxol and atp

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abcb1, mdr1, pgy1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: t-rex 293

Authors:

D.Kurre,A.Alam

Key ref:

D.Kurre et al. Structural insights into binding-Site access and liga recognition by human abcb1.. Embo j, . PubMed id: 39806099

Date:

25-Jul-24 Release date: 22-Jan-25

Protein chain

P08183  (MDR1_HUMAN) -  ATP-dependent translocase ABCB1 from Homo sapiens

Seq: 1280 a.a.

Struc: 1158 a.a.

Enzyme reactions

• Enzyme class 1: E.C.7.6.2.1 - P-type phospholipid transporter.
• Reaction: ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2

ATP (Bound ligand (Het Group name = ATP) corresponds exactly) + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2

• Enzyme class 2: E.C.7.6.2.2 - ABC-type xenobiotic transporter.
• Reaction: ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

ATP (Bound ligand (Het Group name = ATP) corresponds exactly) + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site