PDBsum entry 9cjs

Hydrolase/inhibitor

PDB id: 9cjs

Contents

Protein chain

301 a.a.

Ligands

FHR

Waters ×48

PDB id:

9cjs

Name:

Hydrolase/inhibitor

Title:

X-ray crystal structure of sars-cov-2 main protease triple mutants in complex with bofutrelvir

Structure:

3c-like proteinase nsp5. Chain: a. Synonym: 3cl-pro,3clp,main protease,mpro,non-structural protein 5, nsp5,sars coronavirus main proteinase. Engineered: yes. Mutation: yes

Source:

Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049. Gene: rep, 1a-1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.09Å R-factor: 0.216 R-free: 0.278

Authors:

M.A.Esler,K.Shi,R.S.Harris,H.Aihara

Key ref:

M.A.Esler et al. X-Ray crystal structure of sars-Cov-2 main protease t mutants in complex with bofutrelvir. To be published, .

Date:

07-Jul-24 Release date: 09-Jul-25

Protein chain

P0DTD1  (R1AB_SARS2) -  NSP5 - main protease (306 aa)

Seq: 306 a.a.

Struc: 301 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.22.69 - Sars coronavirus main proteinase.