PDBsum entry 9ca0

Isomerase/DNA

PDB id: 9ca0

Contents

Protein chains

612 a.a.

161 a.a.

DNA/RNA

Metals

_MN

PDB id:

9ca0

Name:

Isomerase/DNA

Title:

Human top3b-tdrd3 core complex in DNA post-cleavage state

Structure:

DNA topoisomerase 3-beta-1. Chain: a. Synonym: DNA topoisomerase iii beta-1. Engineered: yes. Tudor domain-containing protein 3. Chain: b. Fragment: duf-ob fold (unp residues 1-161). Synonym: tdrd3. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: top3b, top3b1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: tdrd3. Synthetic: yes. Organism_taxid: 9606

Authors:

X.Yang,X.Chen,W.Yang,Y.Pommier

Key ref:

X.Yang et al. Structural insights into human topoisomerase 3-Beta d RNA catalytic cycles and topo-Gate dynamics. To be published, . PubMed id: 39828754

Date:

16-Jun-24 Release date: 17-Jul-24

Protein chain

O95985  (TOP3B_HUMAN) -  DNA topoisomerase 3-beta-1 from Homo sapiens

Seq: 862 a.a.

Struc: 612 a.a.

Protein chain

Q9H7E2  (TDRD3_HUMAN) -  Tudor domain-containing protein 3 from Homo sapiens

Seq: 651 a.a.

Struc: 161 a.a.

DNA/RNA chains

T-A-C-T-A-A-A 7 bases

A-T-T 3 bases

Enzyme reactions

• Enzyme class: Chain A: E.C.5.6.2.1 - Dna topoisomerase.