PDBsum entry 9asm

RNA binding protein/RNA

PDB id: 9asm

Contents

Protein chains

916 a.a.

240 a.a.

24 a.a.

DNA/RNA

Metals

_CA ×2

_ZN ×2

Waters ×2

PDB id:

9asm

Name:

RNA binding protein/RNA

Title:

Human drosha and dgcr8 in complex with pri-let-7f1

Structure:

Isoform 4 of drosha. Chain: a. Synonym: ribonuclease 3,ribonuclease iii,rnase iii,p241. Engineered: yes. Microprocessor complex subunit dgcr8. Chain: b, c. Synonym: digeorge syndrome critical region 8. Engineered: yes. Pri-let-7f1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: drosha, rn3, rnase3l, rnasen. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: dgcr8, c22orf12, dgcrk6, lp4941. Expressed in: escherichia coli. Expression_system_taxid: 562

Authors:

A.Garg,L.Joshua-Tor

Key ref:

A.Garg and l.joshua-tor Rnai_protein_f1. To be published, . PubMed id: 39368465

Date:

26-Feb-24 Release date: 04-Sep-24

Protein chain

Q9NRR4  (RNC_HUMAN) -  Ribonuclease 3 from Homo sapiens

Seq: 1374 a.a.

Struc: 916 a.a.

Protein chain

Q8WYQ5  (DGCR8_HUMAN) -  Microprocessor complex subunit DGCR8 from Homo sapiens

Seq: 773 a.a.

Struc: 240 a.a.

Protein chain

Q8WYQ5  (DGCR8_HUMAN) -  Microprocessor complex subunit DGCR8 from Homo sapiens

Seq: 773 a.a.

Struc: 24 a.a.

DNA/RNA chain

A-A-A-C-A-U-U-G-C-U-C-U-A-U-C-A-G-A-G-U-G-A-G-G-U-A-G-U-A-G-A-U-U-G-U-A-U-A-G- 95 bases

Enzyme reactions

• Enzyme class: Chain A: E.C.3.1.26.3 - ribonuclease Iii.
• Reaction: Endonucleolytic cleavage to 5'-phosphomonoester.