PDBsum entry 9ask

Transferase, DNA binding protein

PDB id: 9ask

Contents

Protein chains

741 a.a.

PDB id:

9ask

Name:

Transferase, DNA binding protein

Title:

Human DNA polymerase theta helicase domain dimer, apo-form

Structure:

DNA polymerase theta. Chain: a, b. Synonym: DNA polymerase eta. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: polq, polh. Expressed in: escherichia coli. Expression_system_taxid: 562

Authors:

F.Ito,Z.Li,X.S.Chen

Key ref:

F.Ito et al. Structural basis for pol theta-Helicase DNA binding a microhomology-Mediated end-Joining.. Biorxiv, . PubMed id: 38895274

Date:

26-Feb-24 Release date: 26-Jun-24

Protein chains

O75417  (DPOLQ_HUMAN) -  DNA polymerase theta from Homo sapiens

Seq: 2590 a.a.

Struc: 741 a.a.

Enzyme reactions

• Enzyme class 2: E.C.2.7.7.49 - RNA-directed Dna polymerase.
• Reaction: DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
• Enzyme class 3: E.C.2.7.7.7 - DNA-directed Dna polymerase.
• Reaction: DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
• Enzyme class 4: E.C.3.6.4.12 - Dna helicase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site