PDBsum entry 8z3f

Metal binding protein

PDB id: 8z3f

Contents

Protein chains

183 a.a.

45 a.a.

Metals

_CA ×3

Waters ×261

PDB id:

8z3f

Name:

Metal binding protein

Title:

Complex structure of cib2 and tmc1 cr1

Structure:

Calcium and integrin-binding family member 2. Chain: a. Synonym: kinase-interacting protein 2,kip 2. Engineered: yes. Mutation: yes. Transmembrane channel-like protein 1. Chain: b. Synonym: beethoven protein,deafness protein,transmembrane cochlear- expressed protein 1.

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: cib2, kip2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: tmc1, bth, dn.

Resolution:

1.74Å R-factor: 0.179 R-free: 0.200

Authors:

S.Wu,L.Lin,Q.Lu

Key ref:

S.Wu et al. Mechano-Electrical transduction components tmc1-Cib2 a ca 2+ -Induced conformational change linked to hear loss.. Dev cell, . PubMed id: 39889697

Date:

15-Apr-24 Release date: 19-Feb-25

Protein chain

Q9Z309  (CIB2_MOUSE) -  Calcium and integrin-binding family member 2 from Mus musculus

Seq: 187 a.a.

Struc: 183 a.a.*

Protein chain

Q8R4P5  (TMC1_MOUSE) -  Transmembrane channel-like protein 1 from Mus musculus

Seq: 757 a.a.

Struc: 45 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)