PDBsum entry 8y1e

Viral protein/hydrolase

PDB id: 8y1e

Contents

Protein chains

1208 a.a.

345 a.a.

Ligands

NAG-NAG-MAN-MAN-MAN-MAN ×3

NAG-NAG ×12

NAG ×51

PDB id:

8y1e

Name:

Viral protein/hydrolase

Title:

3up-tm conformation of hku1-b s protein after incubation of the receptor

Structure:

Spike glycoprotein. Chain: a, b, c. Synonym: s glycoprotein,e2,peplomer protein. Engineered: yes. Transmembrane protease serine 2. Chain: d, e, f. Synonym: serine protease 10. Engineered: yes

Source:

Human coronavirus hku1 (isolate n2). Organism_taxid: 443240. Gene: s, 3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606. Gene: tmprss2, prss10.

Authors:

L.Y.Xia,Y.Y.Zhang,Q.Zhou

Key ref:

L.Xia et al. Structural basis for the recognition of hcov-Hku1 by tmprss2.. Cell res, . PubMed id: 38641728

Date:

24-Jan-24 Release date: 01-May-24

Protein chains

Q14EB0  (SPIKE_CVHN2) -  Spike glycoprotein from Human coronavirus HKU1 (isolate N2)

Seq: 1351 a.a.

Struc: 1208 a.a.*

Protein chains

O15393  (TMPS2_HUMAN) -  Transmembrane protease serine 2 from Homo sapiens

Seq: 492 a.a.

Struc: 345 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains D, E, F: E.C.3.4.21.122 - transmembrane protease serine 2.