PDBsum entry 8xwt

Viral protein

PDB id: 8xwt

Contents

Protein chain

305 a.a.

Ligands

SER-GLY-VAL-THR-PHE-GLN-SER-ALA-VAL-LYS

Waters ×233

PDB id:

8xwt

Name:

Viral protein

Title:

Crystal structure of sars-cov-2 3clpro-l50f mutant with its peptidyl substrate

Structure:

3c-like proteinase nsp5. Chain: a. Synonym: 3cl-pro,3clp,main protease,mpro,non-structural protein 5, nsp5,sars coronavirus main proteinase. Engineered: yes. Mutation: yes. Cys-ser-gly-val-thr-phe-gln-ser-ala-val-lys-arg-thr-ile. Chain: b. Engineered: yes

Source:

Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049. Gene: rep, 1a-1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. 2019-ncov, sars-cov-2. Organism_taxid: 2697049

Resolution:

1.70Å R-factor: 0.217 R-free: 0.250

Authors:

L.J.Zhang,Q.Hu

Key ref:

L.J.Zhang and q.hu Crystal structure of sars-Cov-2 3clpro-L50f mutant wi peptidyl substrate. To be published, .

Date:

16-Jan-24 Release date: 22-Jan-25

Protein chain

P0DTD1  (R1AB_SARS2) -

Enzyme reactions

• Enzyme class: E.C.3.4.22.69 - Sars coronavirus main proteinase.