PDBsum entry 8x7h

Cytosolic protein

PDB id: 8x7h

Contents

Protein chains

162 a.a.

105 a.a.

163 a.a.

164 a.a.

Ligands

YBI ×4

GOL ×8

Waters ×64

PDB id:

8x7h

Name:

Cytosolic protein

Title:

Crystal structure of the ternary complex of gid4-protac(nep162)- brd4(bd1).

Structure:

Glucose-induced degradation protein 4 homolog. Chain: a, c, e, g. Synonym: vacuolar import and degradation protein 24 homolog. Engineered: yes. Bromodomain-containing protein 4. Chain: b, d, f, h. Synonym: protein hunk1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gid4, c17orf39, vid24. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: brd4, hunk1. Expression_system_taxid: 562

Resolution:

2.90Å R-factor: 0.239 R-free: 0.301

Authors:

C.Dong,X.Yan,Y.Li

Key ref:

C.Dong et al. Crystal structure of 162. To be published, . PubMed id: 40295770

Date:

24-Nov-23 Release date: 26-Mar-25

Protein chain

Q8IVV7  (GID4_HUMAN) -  Glucose-induced degradation protein 4 homolog from Homo sapiens

Seq: 300 a.a.

Struc: 162 a.a.*

Protein chains

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 105 a.a.

Protein chain

Q8IVV7  (GID4_HUMAN) -  Glucose-induced degradation protein 4 homolog from Homo sapiens

Seq: 300 a.a.

Struc: 163 a.a.*

Protein chains

Q8IVV7  (GID4_HUMAN) -  Glucose-induced degradation protein 4 homolog from Homo sapiens

Seq: 300 a.a.

Struc: 164 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)