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PDBsum entry 8w3d
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Transferase/transferase inhibitor
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PDB id
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8w3d
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Tas-120 covalent structure with fgfr2 molecular brake mutant
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Structure:
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Fibroblast growth factor receptor 2. Chain: a, b, c, d. Synonym: fgfr-2,k-sam,kgfr,keratinocyte growth factor receptor. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.04Å
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R-factor:
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0.220
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R-free:
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0.250
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Authors:
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I.D.Hoffman,K.J.Nelson,D.C.Bensen,J.B.Bailey
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Key ref:
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L.Goyal
et al.
A model for decoding resistance in precision oncology acquired resistance to fgfr inhibitors in cholangiocarcinoma..
Ann oncol,
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PubMed id:
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Date:
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22-Feb-24
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Release date:
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01-Jan-25
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PROCHECK
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Headers
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References
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P21802
(FGFR2_HUMAN) -
Fibroblast growth factor receptor 2 from Homo sapiens
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Seq:
Struc:
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821 a.a.
298 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
