PDBsum entry 8vux

Membrane protein

PDB id: 8vux

Contents

Protein chains

1005 a.a.

Ligands

Y01 ×2

1SY

PDB id:

8vux

Name:

Membrane protein

Title:

Cryo-em structure of human abc transporter (habcc1) bound to cgamp

Structure:

Multidrug resistance-associated protein 1. Chain: a, b. Synonym: atp-binding cassette sub-family c member 1,glutathione-s- conjugate-translocating atpase abcc1,leukotrienE C(4) transporter, ltc4 transporter. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abcc1, mrp, mrp1. Expressed in: homo sapiens. Expression_system_taxid: 9606

Authors:

O.Shinde,P.Li

Key ref:

O.Shinde and p.li Cryoem structure of human abc transporter (habcc1) bo cgamp at 3.54 angstroms resolution.. To be published, . PubMed id: 39765229

Date:

30-Jan-24 Release date: 25-Dec-24

Protein chains

P33527  (MRP1_HUMAN) -  Multidrug resistance-associated protein 1 from Homo sapiens

Seq: 1531 a.a.

Struc: 1005 a.a.

Enzyme reactions

• Enzyme class 2: E.C.7.6.2.2 - ABC-type xenobiotic transporter.
• Reaction: ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

ATP + H2O + xenobioticSide 1 = ADP (Bound ligand (Het Group name = 1SY) matches with 46.94% similarity) + phosphate + xenobioticSide 2

• Enzyme class 3: E.C.7.6.2.3 - ABC-type glutathione-S-conjugate transporter.
• Reaction: an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H⁺

S-substituted glutathione(in) + ATP + H2O = S-substituted glutathione(out) + ADP (Bound ligand (Het Group name = 1SY) matches with 46.94% similarity) + phosphate + H(+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site