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PDBsum entry 8vqe
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Signaling protein
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PDB id
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8vqe
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PDB id:
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| Name: |
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Signaling protein
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Title:
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Homodimeric structure of her2 s310f extracellular region
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Structure:
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Receptor tyrosine-protein kinase erbb-2/higg1 fc domain fusion. Chain: a, b. Synonym: metastatic lymph node gene 19 protein,mln 19,proto-oncogene neu,proto-oncogenE C-erbb-2,tyrosine kinase-type cell surface receptor her2,p185erbb2. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606
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Authors:
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I.Bang,S.Koide
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Key ref:
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I.Bang
et al.
Selective targeting of oncogenic hotspot mutations of her2 extracellular domain..
Nat chem biol,
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PubMed id:
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Date:
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18-Jan-24
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Release date:
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06-Nov-24
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PROCHECK
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Headers
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References
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P04626
(ERBB2_HUMAN) -
Receptor tyrosine-protein kinase erbB-2 from Homo sapiens
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Seq:
Struc:
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1255 a.a.
502 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
Bound ligand (Het Group name = )
matches with 41.38% similarity
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
