PDBsum entry 8vpp

Transport protein

PDB id: 8vpp

Contents

Protein chains

892 a.a.

372 a.a.

Ligands

KLT

Waters ×2

PDB id:

8vpp

Name:

Transport protein

Title:

Phosphorylated human ncc in complex with chlorthalidone

Structure:

Solute carrier family 12 member 3. Chain: a, b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: slc12a3. Expressed in: homo sapiens. Expression_system_taxid: 9606

Authors:

Y.X.Zhao,E.H.Cao

Key ref:

Y.Zhao et al. (2024). Structural bases for na + -Cl - Cotransporter inhibit thiazide diuretic drugs and activation by kinases.. Nat commun, 15, 7006. PubMed id: 39143061

Date:

16-Jan-24 Release date: 04-Sep-24

Protein chain

J3QSS1  (J3QSS1_HUMAN) -  Solute carrier family 12 member 3 from Homo sapiens

Seq: 1020 a.a.

Struc: 892 a.a.*

Protein chain

J3QSS1  (J3QSS1_HUMAN) -  Solute carrier family 12 member 3 from Homo sapiens

Seq: 1020 a.a.

Struc: 372 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)