PDBsum entry 8ttp

Hydrolase

PDB id: 8ttp

Contents

Protein chains

358 a.a.

Ligands

NXL ×2

EDO ×10

PEG ×2

IPA ×2

Waters ×887

PDB id:

8ttp

Name:

Hydrolase

Title:

Crystal structure of class c beta-lactamase from escherichia coli in complex with avibactam

Structure:

Beta-lactamase. Chain: a, b. Engineered: yes

Source:

Escherichia coli a35218r. Organism_taxid: 1269009. Gene: bla(ampc-ec31). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.43Å R-factor: 0.161 R-free: 0.189

Authors:

C.Chang,N.Maltseva,M.Endres,A.Joachimiak,Center For Structural Biology Of Infectious Diseases (Csbid)

Key ref:

C.Chang et al. Crystal structure of class c beta-Lactamase from esch coli in complex with avibactam. To be published, .

Date:

14-Aug-23 Release date: 06-Sep-23

Protein chains

A0A377KDY3  (A0A377KDY3_ECOLX) -  Beta-lactamase from Escherichia coli

Seq: 388 a.a.

Struc: 358 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)