PDBsum entry 8t5k

Antiviral protein

PDB id: 8t5k

Contents

Protein chain

180 a.a.

Ligands

YGI

Waters ×86

PDB id:

8t5k

Name:

Antiviral protein

Title:

Crystal structure of sting ctd in complex with bdw-oh

Structure:

Stimulator of interferon genes protein. Chain: b. Fragment: c-terminal domain (unp residues 154-341). Synonym: hsting,endoplasmic reticulum interferon stimulator,eris, mediator of irf3 activation,hmita,transmembrane protein 173. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sting1, eris, mita, sting, tmem173. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.95Å R-factor: 0.199 R-free: 0.230

Authors:

Y.Li,P.Li,D.Sun

Key ref:

Z.Tang et al. Structural and biological evaluations of a non-Nucleo sting agonist specific for human sting a230 variants.. Biorxiv, . PubMed id: 37425806

Date:

13-Jun-23 Release date: 12-Jul-23

Protein chain

Q86WV6  (STING_HUMAN) -  Stimulator of interferon genes protein from Homo sapiens

Seq: 379 a.a.

Struc: 180 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)