PDBsum entry 8st1

Transport protein

PDB id: 8st1

Contents

Protein chains

375 a.a.

365 a.a.

218 a.a.

218 a.a.

Ligands

NAG-NAG-BMA ×2

NAG ×6

ACH ×3

Metals

_CA ×4

_NA

Waters ×5

PDB id:

8st1

Name:

Transport protein

Title:

The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

Structure:

Neuronal acetylcholine receptor subunit alpha-4. Chain: a, b, d. Fragment: unp residues 27-364,582-627. Engineered: yes. Neuronal acetylcholine receptor subunit beta-2. Chain: c, e. Fragment: unp residues 26-355,442-502. Engineered: yes. Igg1 kappa light chain.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: chrna4, nacra4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: chrnb2. Mus musculus. Mouse.

Authors:

G.Kang,R.E.Hibbs

Key ref:

G.Kang et al. Structure of the 3alpha2beta stoichiometry of the hum alpha4beta2 nicotinic acetylcholine receptor in compl acetylcholine and calcium. To be published, . PubMed id: 38454578

Date:

09-May-23 Release date: 07-Feb-24

Protein chains

P43681  (ACHA4_HUMAN) -  Neuronal acetylcholine receptor subunit alpha-4 from Homo sapiens

Seq: 627 a.a.

Struc: 375 a.a.*

Protein chains

P17787  (ACHB2_HUMAN) -  Neuronal acetylcholine receptor subunit beta-2 from Homo sapiens

Seq: 502 a.a.

Struc: 365 a.a.

Protein chains

No UniProt id for this chain

Struc: 218 a.a.

Protein chains

No UniProt id for this chain

Struc: 218 a.a.

* PDB and UniProt seqs differ at 41 residue positions (black crosses)