PDBsum entry 8srm

Immune system

PDB id: 8srm

Contents

Protein chains

428 a.a.

235 a.a.

205 a.a.

45 a.a.

PDB id:

8srm

Name:

Immune system

Title:

Structure of human ulk1 complex core (2:2:2 stoichiometry) of the atg13(450-517) mutant

Structure:

Rb1-inducible coiled-coil protein 1. Chain: a, b. Synonym: fak family kinase-interacting protein of 200 kda,fip200. Engineered: yes. Serine/threonine-protein kinase ulk1. Chain: c, d. Synonym: autophagy-related protein 1 homolog,atg1,hatg1,unc-51-like kinase 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rb1cc1, kiaa0203, rbicc. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: ulk1, kiaa0722. Gene: atg13, kiaa0652. Expression_system_taxid: 9606

Authors:

M.Chen,J.H.Hurley

Key ref:

M.Chen et al. Structure and activation of the human autophagy-Initi ulk1c:pi3kc3-C1 supercomplex. Biorxiv, .

Date:

05-May-23 Release date: 21-Jun-23

Protein chain

Q8TDY2  (RBCC1_HUMAN) -  RB1-inducible coiled-coil protein 1 from Homo sapiens

Seq: 1594 a.a.

Struc: 428 a.a.

Protein chain

Q8TDY2  (RBCC1_HUMAN) -  RB1-inducible coiled-coil protein 1 from Homo sapiens

Seq: 1594 a.a.

Struc: 235 a.a.

Protein chains

O75385  (ULK1_HUMAN) -  Serine/threonine-protein kinase ULK1 from Homo sapiens

Seq: 1050 a.a.

Struc: 205 a.a.

Protein chains

O75143  (ATG13_HUMAN) -  Autophagy-related protein 13 from Homo sapiens

Seq: 517 a.a.

Struc: 45 a.a.

Enzyme reactions

• Enzyme class: Chains C, D: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site