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PDBsum entry 8sph
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protein ligands metals Protein-protein interface(s) links
Hydrolase/viral protein PDB id
8sph

 

 

 

 

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Contents
Protein chains
596 a.a.
193 a.a.
Ligands
NAG-NAG-BMA ×2
NAG-NAG ×6
NAG-NAG-BMA-NAG
EDO ×4
NAG ×3
Metals
_ZN ×2
_CL ×2
Waters ×29
PDB id:
8sph
Name: Hydrolase/viral protein
Title: Crystal structure of chimeric omicron rbd (strain xbb.1) complexed with human ace2
Structure: Angiotensin-converting enzyme 2. Chain: a, b. Fragment: unp residues 19-615. Synonym: ace-related carboxypeptidase,angiotensin-converting enzyme homolog,aceh,metalloprotease mprot15. Engineered: yes. Spike protein s1. Chain: e, f. Fragment: receptor-binding domain.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ace2, unq868/pro1885. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049.
Resolution:
2.71Å     R-factor:   0.222     R-free:   0.283
Authors: W.Zhang,K.Shi,H.Aihara,F.Li
Key ref: W.Zhang et al. Structural evolution of sars-Cov-2 omicron in human r recognition. To be published, . PubMed id: 37578233
Date:
03-May-23     Release date:   02-Aug-23    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Q9BYF1  (ACE2_HUMAN) -  Angiotensin-converting enzyme 2 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		805 a.a.
596 a.a.
Protein chains
P0DTC2  (SPIKE_SARS2) -  Spike glycoprotein from Severe acute respiratory syndrome coronavirus 2
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1273 a.a.
193 a.a.*
Protein chains
P59594  (SPIKE_CVHSA) -  Spike glycoprotein from Severe acute respiratory syndrome coronavirus
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1255 a.a.
193 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 58 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 2: Chains A, B: E.C.3.4.17.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 3: Chains A, B: E.C.3.4.17.23  - angiotensin-converting enzyme 2.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: angiotensin II + H2O = angiotensin-1-7 + L-phenylalanine
angiotensin II
 + H2O
 = angiotensin-(1-7)
 + L-phenylalanine
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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