PDBsum entry 8sos

Immune system

PDB id: 8sos

Contents

Protein chains

271 a.a.

98 a.a.

127 a.a.

Ligands

FO4 ×2

NAG ×4

Waters ×572

PDB id:

8sos

Name:

Immune system

Title:

Human cd1d presenting sphingomyelin c24:1 in complex with vhh nanobody 1d17

Structure:

Antigen-presenting glycoprotein cd1d. Chain: a, e. Synonym: r3g1. Engineered: yes. Beta-2-microglobulin. Chain: b, f. Fragment: unp residues 21-119. Engineered: yes. Nanobody vhh id17.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cd1d. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293s. Gene: b2m, cdabp0092, hdcma22p. Lama glama.

Resolution:

2.33Å R-factor: 0.210 R-free: 0.230

Authors:

A.Shahine,J.Rossjohn

Key ref:

R.Lameris et al. (2023). Enhanced cd1d phosphatidylserine presentation using a single-Domain antibody promotes immunomodulatory cd1d interactions.. J immunother cancer, 11, . PubMed id: 38040419

Date:

29-Apr-23 Release date: 13-Dec-23

Protein chains

P05412  (JUN_HUMAN) -  Transcription factor Jun from Homo sapiens

Seq: 331 a.a.

Struc: 271 a.a.*

Protein chains

P15813  (CD1D_HUMAN) -  Antigen-presenting glycoprotein CD1d from Homo sapiens

Seq: 335 a.a.

Struc: 271 a.a.

Protein chains

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 98 a.a.

Protein chains

No UniProt id for this chain

Struc: 127 a.a.

* PDB and UniProt seqs differ at 249 residue positions (black crosses)