PDBsum entry 8sno

Membrane protein/hydrolase

PDB id: 8sno

Contents

Protein chains

227 a.a.

491 a.a.

Metals

_CA

PDB id:

8sno

Name:

Membrane protein/hydrolase

Title:

Structure of mature human adam17/irhom2 sheddase complex, conformation 2

Structure:

Disintegrin and metalloproteinase domain-containing protein 17. Chain: a. Synonym: adam 17,snake venom-like protease,tnf-alpha convertase,tnf- alpha-converting enzyme. Engineered: yes. Inactive rhomboid protein 2. Chain: b. Synonym: irhom2,rhomboid 5 homolog 2,rhomboid family member 2,

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: adam17, csvp, tace. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: rhbdf2, irhom2, rhbdl5, rhbdl6. Expression_system_taxid: 9606

Authors:

H.Zhao,Y.Dai,Y.Wang,C.H.Lee

Key ref:

H.Zhao et al. Structure of mature human adam17/irhom2 sheddase comp conformation 2. To be published, . PubMed id: 38781971

Date:

27-Apr-23 Release date: 29-May-24

Protein chain

P78536  (ADA17_HUMAN) -  Disintegrin and metalloproteinase domain-containing protein 17 from Homo sapiens

Seq: 824 a.a.

Struc: 227 a.a.

Protein chain

Q6PJF5  (RHDF2_HUMAN) -  Inactive rhomboid protein 2 from Homo sapiens

Seq: 856 a.a.

Struc: 491 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.4.24.86 - Adam 17 endopeptidase.
• Cofactor: Zn(2+)