PDBsum entry 8sml

Hydrolase/immune system

PDB id: 8sml

Contents

Protein chains

570 a.a.

106 a.a.

121 a.a.

Metals

_CA ×6

PDB id:

8sml

Name:

Hydrolase/immune system

Title:

Hpad4 bound to inhibitory fab hi365

Structure:

Protein-arginine deiminase type-4. Chain: a, d. Synonym: hl-60 pad,peptidylarginine deiminase iv,protein-arginine deiminase type iv. Engineered: yes. Fab hi365 light chain. Chain: b, e. Engineered: yes. Fab hi365 heavy chain.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Variant: 9606. Gene: padi4, pad4, padi5, pdi5. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_atcc_number: 562. Expression_system_taxid: 562

Authors:

A.Maker,K.A.Verba

Key ref:

X.Zhou et al. Antibody discovery identifies regulatory mechanisms o protein arginine deiminase 4.. Nat chem biol, . PubMed id: 38308046

Date:

26-Apr-23 Release date: 06-Mar-24

Protein chains

Q9UM07  (PADI4_HUMAN) -  Protein-arginine deiminase type-4 from Homo sapiens

Seq: 663 a.a.

Struc: 570 a.a.*

Protein chains

No UniProt id for this chain

Struc: 106 a.a.

Protein chains

No UniProt id for this chain

Struc: 121 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, D: E.C.3.5.3.15 - protein-arginine deiminase.
• Reaction: L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site