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PDBsum entry 8sj0
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Transferase/DNA
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PDB id
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8sj0
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PDB id:
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| Name: |
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Transferase/DNA
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Title:
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Structure of ternary complex of cgas with dsdna and bound 2'-datp
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Structure:
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Cyclic gmp-amp synthase. Chain: a, c. Fragment: catalytic domain (unp residues 147-507). Synonym: cgamp synthase,cgas,m-cgas,2'3'-cgamp synthase,mab-21 domain-containing protein 1. Engineered: yes. Palindromic dna18. Chain: e, f, i, j. Engineered: yes
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Source:
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Mus musculus. House mouse. Organism_taxid: 10090. Gene: cgas, mb21d1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
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Resolution:
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2.55Å
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R-factor:
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0.194
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R-free:
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0.237
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Authors:
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S.Wu,J.Sohn
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Key ref:
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S.Wu
and
j.sohn
Structure of ternary complex of cgas with dsdna and b 2'-Datp.
To be published,
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PubMed id:
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Date:
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17-Apr-23
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Release date:
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24-Apr-24
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PROCHECK
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Headers
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References
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Q8C6L5
(CGAS_MOUSE) -
Cyclic GMP-AMP synthase from Mus musculus
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Seq:
Struc:
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507 a.a.
356 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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A-T-C-T-G-T-A-C-A-T-G-T-A-C-A-G-A-T
18 bases
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A-T-C-T-G-T-A-C-A-T-G-T-A-C-A-G-A-T
18 bases
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A-T-C-T-G-T-A-C-A-T-G-T-A-C-A-G-A-T
18 bases
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A-T-C-T-G-T-A-C-A-T-G-T-A-C-A-G-A-T
18 bases
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Enzyme class:
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E.C.2.7.7.86
- cyclic GMP-AMP synthase.
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Reaction:
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GTP + ATP = 2',3'-cGAMP + 2 diphosphate
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GTP
Bound ligand (Het Group name = )
matches with 96.77% similarity
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+
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ATP
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=
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2',3'-cGAMP
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+
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2
×
diphosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
