PDBsum entry 8sgo

Transport protein/immune system

PDB id: 8sgo

Contents

Protein chains

334 a.a.

338 a.a.

333 a.a.

105 a.a.

116 a.a.

Ligands

NAG-NAG-BMA ×3

NAG-NAG-BMA-MAN-MAN-MAN-MAN-MAN-MAN-MAN

NAG-NAG

NAG ×2

ABU ×2

PTY ×6

Q3G

A8W

PDB id:

8sgo

Name:

Transport protein/immune system

Title:

Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus pregnenolone sulfate

Structure:

Gamma-aminobutyric acid receptor subunit beta-2. Chain: a, c. Synonym: gaba(a) receptor subunit beta-2. Engineered: yes. Gamma-aminobutyric acid receptor subunit alpha-1. Chain: b, d. Synonym: gaba(a) receptor subunit alpha-1. Engineered: yes. Gamma-aminobutyric acid receptor subunit gamma-2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gabrb2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gabra1. Gene: gabrg2. Mus musculus.

Authors:

D.H.Legesse,C.Fan,J.Teng,Y.Zhuang,R.J.Howard,C.M.Noviello,E.Lindahl, R.E.Hibbs

Key ref:

R.E.Hibbs and d.h.legesse Human gabaa receptor alpha1-Beta2-Gamma2 subtype in c with gaba plus allopregnanolone. Nat commun, . PubMed id: 37607940

Date:

12-Apr-23 Release date: 30-Aug-23

Protein chains

P47870  (GBRB2_HUMAN) -  Gamma-aminobutyric acid receptor subunit beta-2 from Homo sapiens

Seq: 512 a.a.

Struc: 334 a.a.*

Protein chains

P14867  (GBRA1_HUMAN) -  Gamma-aminobutyric acid receptor subunit alpha-1 from Homo sapiens

Seq: 456 a.a.

Struc: 338 a.a.*

Protein chain

P18507  (GBRG2_HUMAN) -  Gamma-aminobutyric acid receptor subunit gamma-2 from Homo sapiens

Seq: 475 a.a.

Struc: 333 a.a.*

Protein chains

No UniProt id for this chain

Struc: 105 a.a.

Protein chains

No UniProt id for this chain

Struc: 116 a.a.

* PDB and UniProt seqs differ at 39 residue positions (black crosses)