PDBsum entry 8sdo

Protein binding

PDB id: 8sdo

Contents

Protein chain

130 a.a.

Ligands

CYS-GLY-ARG-GLY-ALY-GLY

Waters ×168

PDB id:

8sdo

Name:

Protein binding

Title:

Atad2 bromodomain in complex with "oncohistone" mutation h4s1ck5ac (res 1-15) ligand

Structure:

Atpase family aaa domain-containing protein 2. Chain: a. Synonym: aaa nuclear coregulator cancer-associated protein,ancca. Engineered: yes. Mutation: yes. Histone h4. Chain: b. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: atad2, l16, pro2000. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.01Å R-factor: 0.202 R-free: 0.231

Authors:

K.L.Malone,J.C.Nix,K.C.Glass

Key ref:

M.Phillips et al. (2024). Impact of combinatorial histone modifications on acetyllysine recognition by the atad2 and atad2b bromodomains.. J med chem, 67, 8186. PubMed id: 38733345

Date:

07-Apr-23 Release date: 05-Jun-24

Protein chain

Q6PL18  (ATAD2_HUMAN) -  ATPase family AAA domain-containing protein 2 from Homo sapiens

Seq: 1390 a.a.

Struc: 130 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.6.1.- - ?????