PDBsum entry 8sbt

Chaperone

PDB id: 8sbt

Contents

Protein chain

210 a.a.

Ligands

ZUY

Metals

_MG

Waters ×361

PDB id:

8sbt

Name:

Chaperone

Title:

Structure of human hsp90-alpha bound to purine inhibitor pu-h36

Structure:

Heat shock protein hsp 90-alpha. Chain: a. Synonym: heat shock 86 kda,hsp86,lipopolysaccharide-associated protein 2,lps-associated protein 2,renal carcinoma antigen ny-ren-38. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hsp90aa1, hsp90a, hspc1, hspca. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.50Å R-factor: 0.174 R-free: 0.197

Authors:

N.S.Que,D.T.Gewirth

Key ref:

N.S.Que and d.t.gewirth Selective binding to grp94 and hsp90. To be published, . PubMed id: 39473058

Date:

04-Apr-23 Release date: 09-Oct-24

Protein chain

P07900  (HS90A_HUMAN) -  Heat shock protein HSP 90-alpha from Homo sapiens

Seq: 732 a.a.

Struc: 210 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.4.10 - non-chaperonin molecular chaperone ATPase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

ATP + H2O = ADP (Bound ligand (Het Group name = ZUY) matches with 40.54% similarity) + phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site