PDBsum entry 8sbl

Immune system

PDB id: 8sbl

Contents

Protein chains

276 a.a.

100 a.a.

Ligands

LEU-TYR-LEU-PRO-VAL-ARG-VAL-LEU-ILE ×4

PDB id:

8sbl

Name:

Immune system

Title:

Structure of hla-a 24:02 In complex with peptide, lylpvrvli

Structure:

Mhc class i antigen. Chain: a, d, g, j. Engineered: yes. Beta-2-microglobulin. Chain: b, e, h, k. Fragment: unp residues 21-119. Engineered: yes. Leu-tyr-leu-pro-val-arg-val-leu-ile. Chain: c, f, i, l.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes. Organism_taxid: 9606

Resolution:

3.00Å R-factor: 0.198 R-free: 0.270

Authors:

L.Mallik,M.C.Young,N.G.Sgourakis

Key ref:

Y.Sun et al. Structural principles of peptide-Centric chimeric ant receptor recognition guide therapeutic expansion. Sci immunol, . PubMed id: 38039376

Date:

03-Apr-23 Release date: 06-Dec-23

Protein chains

A0A5H2UYS3  (A0A5H2UYS3_HUMAN) -  MHC class I antigen from Homo sapiens

Seq: 367 a.a.

Struc: 276 a.a.

Protein chains

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)