PDBsum entry 8sag

Metal binding protein

PDB id: 8sag

Contents

Protein chain

257 a.a.

Ligands

GOL

ZUS

Metals

_ZN

Waters ×224

PDB id:

8sag

Name:

Metal binding protein

Title:

Carbonic anhydrase ii in complex with the coumarin benzene sulfonamide sg1-57

Structure:

Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, cac, carbonic anhydrase ii, ca-ii. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.52Å R-factor: 0.174 R-free: 0.191

Authors:

J.E.Combs,R.Mckenna

Key ref:

J.E.Combs and r.mckenna Carbonic anhydrase ii in complex with novel coumarin sulfonamides. To be published, .

Date:

31-Mar-23 Release date: 03-Apr-24

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 257 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site